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Food and Drug Administration (FDA) approved updated prescribing information for Elevidys that added a boxed warning for serious liver injury, removed the non-ambulatory indication, and expanded immunosuppression and monitoring guidance
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To increase the entropy of water following exposure of HNE-bound hydrophobic regions of the proteins (14), other exposed hydrophobic regions of the same or different proteins will interact, i.e., this leads to protein aggregation of similar or different HNE-bound proteins (15)
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