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There has been one case report that suggests phenytoin treatment in a two-year-old male with epileptic encephalopathy that did not improve with phenobarbital, pyridoxine, pyridoxal phosphate and levetiracetam showed dramatic response to an IV loading dose of phenytoin, followed by a transfer over to carbamazepine to prevent seizure relapses because of the difficulty in maintaining appropriate blood levels of phenytoin [382]
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