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3.2 Iron dysregulation in modulating ferroptosis susceptibility Iron overload, as a key inducer of ferroptosis, disrupts cellular iron homeostasis by interfering with critical components of iron metabolism at both transcriptional and post-transcriptional levels, thereby significantly increasing cellular susceptibility to ferroptosis (59)

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4 Scott Brunner, CEO of the Alliance for Pharmacy Compounding, noted that FDA still must formally adopt the advisers' recommendations before the peptides may be legally compounded