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Although clinical studies specifically addressing AX effects on the brain in obesity are still lacking, preclinical data indicate that AX is able to cross the blood–brain barrier and accumulate in metabolically relevant brain regions, including the hippocampus [87]
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Males pairwise: F 1, 24 = 5.35, q = 0.0012, R ² = 0.189) and early-life HFHS-exposed mice (Females pairwise: F 1, 23 = 10.15, q = 0.002, R ² = 0.316
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