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doi: 10.3389/fmicb.2024.1431954 Received 13 May 2024 Accepted 17 July 2024 Published 21 August 2024 Volume 15 - 2024 Edited by Eugenia Bezirtzoglou, Democritus University of Thrace, Greece Reviewed by Wenzhi Hao, Jinan University, China Bin Wei, Zhejiang University of Technology, China Updates Copyright © 2024 Yang, Quan, Liu, Yang, Chen, You, Hua, Yan, Zhao and Wang
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The legitimate clinical development of Tβ4 is RGN-259, an ophthalmic formulation that has reached Phase 3 trials for dry eye and corneal wounds — real drug development, though not yet an approved product.10 A 2026 scoping review mapping the entire Tβ4/TB-500 literature reached a sober conclusion: the evidence is largely preclinical and unevenly distributed
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