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As expected, overexpression of enzymatically inactive allCys(−) A66C GPX4 exhibited no protective effects against FIN56 and FINO 2 lethality as compared to allCys(−) GPX4, confirming specific protection of allCys(−) A66C GPX4 against RSL3 and ML162, due to the binding of these covalent inhibitors to C66 on allCys(−) A66C GPX4 (Figure 1H and S1H)
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