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Nonetheless, the A2-APM treated group had a notably increased number of total intra-tumoral CD3 + T cells, and most importantly, the proliferation of cytotoxic CD8 + T cells was 4.63- and 1.98-fold higher than the untreated and free antibody groups, respectively (Supplementary Fig
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Additionally, since ferroptosis manifests differently in each T cell type, determining the appropriate dose and adjusting drug combinations for inhibiting or promoting ferroptosis in appropriate T cell subset will be a key focus for future research
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