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Here we found plasma levels of the glycolysis byproduct methylglyoxal (MG) were 4.4-fold higher in ICU patients upon admission that later died (n = 33), and 1.7-fold higher in ICU patients that survived (n = 32),compared to uninfected controls (n = 30)

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DILI chronicity was defined as persistent serum levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), or alkaline phosphatase (ALP) (abnormal liver biochemistry) above baseline after 6 months from DILI onset, regardless of the types of liver injury ( Age and gender matched healthy individuals were enrolled as controls ( Supplementary Material )