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Hydroxytyrosol: A Promising Therapeutic Agent for Mitigating Inflammation and Apoptosis - PMC
What has been established is that DSIP modulates multiple neurochemical and endocrine pathways — including interactions with the hypothalamic-pituitary-adrenal (HPA) axis, endogenous opioid systems, and antioxidant defence mechanisms — giving it a uniquely broad functional profile for a peptide of only nine amino acids
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Some research has used doses up to 8,000 mg per day without a consistent pattern of serious toxicity, though such doses require medical supervision
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