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2.2.2 Mechanisms linking increased Hcy levels to MetS Elevated Hcy levels exert inhibitory effects on the insulin signaling pathway, primarily by inducing IR through the cysteine-homocysteinylation of the pro-insulin receptor
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Nicotinamide (niacinamide) does not cause flushing and has fewer side effects, with nausea and liver toxicity reported only at very high intakes ~3 g/day)
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