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Inside the mitochondria, acyl-CoAs undergo β-oxidation, a cyclic process involving four steps: dehydrogenation to trans-2-enoyl-CoA, hydration to (S)-3-hydroxyacyl-CoA, dehydrogenation to 3-ketoacyl-CoA, and cleavage to acetyl-CoA and a shortened acyl-CoA chain (Fig
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The short chain fatty acid butyrate induces promoter demethylation and reactivation of RARbeta2 in colon cancer cells
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