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In gastric cancer, by contrast, lactylation of Poly(rC)-binding protein 2 (PCBP2) at K115 mediated by the long non-coding RNA BASP1-AS1 specifically blocks the recognition and binding of PCBP2 to the ARIADNE RBR E3 ubiquitin protein ligase 2, inhibits PCBP2 ubiquitination and degradation, and effectively enhances its protein stability, thus exerting an anti-ferroptotic effect to support gastric cancer cell survival [135]
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