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Indeed, transport of aspartate from the mitochondria to the cytosol via the aspartate–glutamate carrier is important for cell survival under certain conditions [89]
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This complex, multimechanistic pathogenesis underpins the notorious resistance of neuropathic pain to conventional analgesics like opioids and NSAIDs, which primarily target nociceptive transmission rather than the maladaptive neural plasticity and immune signaling that are now central to the condition
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