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In the brains of Alzheimer’s disease (AD) patients, pathological features such as reduced mitochondrial membrane potential (ΔΨm), accumulation of mitochondrial peroxides, aberrant opening of the mitochondrial permeability transition pore (mPTP), and mitochondrial iron (mFe) overload are commonly observed—each closely linked to ferroptosis induction (Chen et al., 2023
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Importantly, this regulatory axis challenges the prevailing view of TBK1 as a uniformly pro-autophagic kinase
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