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This swing motion of FnIII-1β², β2β², and β3β² domains upon ligand binding reduces the distance between the two legs, thus facilitating the autophosphorylation of intracellular kinase domains (Fig
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Within 48 h after administration of thiamine (100 mg/day), biotin (10 mg/day), and carnitine (300 mg/day), a remarkable improvement was observed in both clinical and biochemical outcomes (130)
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