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In diet-induced obese (DIO) mouse models, NNMT inhibition with 5-Amino-1MQ was associated with reduced white adipose tissue mass without affecting food intake, suggesting changes in energy expenditure rather than appetite suppression

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2 Available evidence 2.1 The CD38 molecule CD38 is almost ubiquitously expressed, found at varying levels across most tissues, and present both on the cell surface and within cytoplasmic compartments

S Helps optimize energy release for better performance during physical activities