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Side Effects and Safety# FOXO4-DRI Safety Considerations# Observed effects: Transient approximately 10% body weight loss in treated mice, which recovered within days of treatment cessation Off-target risk: If selectivity is imperfect, apoptosis induction in non-senescent cells could cause tissue damage Tissue depletion: In highly senescent tissues, aggressive senescent cell clearance could compromise organ function before regeneration occurs Beneficial senescence: Transient senescence plays roles in wound healing, embryonic development, and tumor suppression
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