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Significant associations were identified between the SNPs PTPN22 rs2476601 and CTLA4 rs3087243 and ME/CFS, especially in patients who reported acute onset of disease after infection (54)
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Bcl3 flox/flox mice were first crossed with Alb-Cre mice, and heterozygous offspring carrying Alb-Cre transgene ( Bcl3 wt/flox -Cre) were crossed with Bcl3 flox/flox mice to generate homozygous mice carrying the Alb-Cre transgene (Alb-Cre- Bcl3 flox/flox ), which were used as liver-specific Bcl3 knockout ( Bcl3 hep-/- ) mice, Other littermates ( Bcl3 fl/fl ) carrying no Alb-Cre transgene were used as wild-type controls
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