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Using the 2341-BRAF V600E model, we have recently demonstrated that BRAF/MEK inhibition alters the tumor immune infiltrate and sensitizes tumors against immune checkpoint blockade by anti-PD-L1 and anti-CTLA4 treatment, which resulted in better clinical outcomes in mice implanted with BRAF V600E mutated high-grade gliomas ( In conclusion, preclinical data obtained using murine glioma models that faithfully recapitulate the human tumors’ genetics and phenotypes have high predictive capacity
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