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Both modifications in IGF-1 LR3 reduce IGFBP affinity substantially, so a given quantity of the analogue produces a stronger receptor-level signal than the same quantity of native IGF-1
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Structural determination and refinement Structural determination of reduced OsDHAR was performed by the molecular replacement method with the MOLREP program by using a homology model of OsDHAR generated by the SWISS-MODEL server 32 and the coordinates of human CLIC1 as the template structure 12
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