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RIP3 levels were found to be elevated after APAP overdose in mice102,103, and RIP3 deficiency provided early protection against liver injury, though this was not sustained102
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and suppressed the expression of NADPH oxidase 1(NOX1), NADPH oxidase 4(NOX4), mitogen-activated protein kinase, NF-κB, and pro-fibronectin expression
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