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Pathogenesis of cataracts. Various cellular pathways are shown in the... | Download Scientific Diagram
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Underscoring the importance of the ER as a ROS producer and sentinel for redox imbalances, the oxygen-sensing HIF1α transcription factor localizes to the ER, where it undergoes a stabilizing Fenton reaction that depends on pO 2 and subsequently enters the nucleus to trigger the hypoxia response 146
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