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𧬠The Polyol Pathway in Hyperglycemia β a classic USMLE mechanism with major clinical consequences. When intracellular glucose rises in insulin-independent tissues, aldose reductase converts glucose into sorbitol and consumes NADPH in
In muscles of aged flies, TFAM and mtDNA have been found to form a more condensed structure than in juveniles (52) impeding access to the mitochondrial transcriptomic machinery with a subsequent reduction of gene expression
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