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p38α MAPK deficiency triggers cytokinesis failure after partial hepatectomy likely through reduced MNK1 phosphorylation Immunohistochemistry of PCNA and phospho-H3 (p-H3) in livers of wild type and p38α knockout mice showed a large increase in the mitotic index (calculated as p-H3/PCNA ratio) in p38α knockout animals after PHx (Fig
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In CRC, abnormal MAPK signaling promotes metabolic reprogramming, notably influencing glucose uptake, oxidative stress regulation, and fatty acid metabolism (158–160)
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