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These cells can be characterized by proliferation, process retraction and upregulation of complement, toll-like receptor (TLR2-4), TNFR1α & β receptors, nitric oxide synthase, heat-shock proteins (HSP27, HSP60, HSP72), chemokine (IL-8) and cytokine (IL-1β, IL-6, CCL2, TNFα) signaling as well as the suppression of anti-inflammatory TGFβ signaling (35, 105)
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3.2 Iron chelators for brain iron accumulation In addition to systemic use, DFO and DFP have been investigated for neurological conditions associated with brain iron accumulation
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