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It is tempting to hypothesize that low circulating levels of 5-HT would be related to serotonergic imbalances that occur in bipolar depression primarily due to chronicity aspects of the illness and drug resistance (genetic and/or epigenetic), while they would be more dependent to alterations in neuroendocrine pathways of stress in bipolar patients presenting “event-responsive” trauma symptoms
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doi: 10.1042/bst0150717
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