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Clearly, dithiothreitol is not a physiological reductant and thioredoxin, the reductant that is active in the catalytic cycle for the other Prdxs, was not effective as a reductant for Prdx6 (21, 34)
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This suggests that peroxisomal H 2 O 2 production could play a secondary signalling role in regulation of hepatic lipid metabolism, especially since little hepatic oxidative damage was observed in this model
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