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More recently, inducible models of senescent cell monitoring, modulation and elimination were generated using Cre-LoxP recombination, such as the p16-LOX-ATTAC and p21-Cre mouse that monitor and manipulate p16 Ink4a+ and p21 high cells in mice, [15,16] facilitating deeper insight into the link between senescent cell burden and organ-specific pathologies
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