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The effect of Se on patients with mild GO was further confirmed by a randomized clinical controlled trial conducted by Marcocci, C
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Importantly, serine/threonine-protein kinase/endoribonuclease IRE1 (IRE1), a regulator of UPR, is required for enhancing insulin biosynthesis in the ER in response to transient glucose, however, in chronic glucotoxic conditions it becomes hyperactive and enhances ER stress (Lipson et al., 2006)
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