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38,39 However, the Wnt/β-catenin signalling pathway is not only positively activated by the above factors but also inhibited by many negative feedback regulators, such as Notum, Tiki, DKKs, Wise/SOST, IGFBP-4, sFRPs, WIF1, and ZNRF3/RNF43
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They play significant roles in gastrointestinal disorders like bile acid diarrhea (BAD), often seen in subjects with diarrhea-predominant irritable bowel syndrome (IBS-D) 12,13
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