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DHT treatment increases the expression of insulin-like growth factor-1 in muscle, which can exert myotrophic as well as neurotrophic effects through retrograde transport
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These biomarkers are included in the diagnostic criteria because they can predict both germline and somatic FAS mutations with a post-test probability from 85 to 97% (87% for vitamin B 12 ) and because they are accessible to facilities without the ability to do genetic analysis or functional assays (Teachey et al., 2005
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