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For instance, peripheral delivery of mesenchymal stem cells can activate vagal sensory neurons innervating the lungs, induce the release of 5-hydroxytryptamine in the dorsal raphe nucleus, and further alleviate depression- and anxiety-like behaviors 78
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The central mechanism driving ferroptosis involves the pathological accumulation of toxic polyunsaturated fatty acid-phospholipid-hydroperoxides (PUFA-PLOOH), resulting from enhanced synthesis and impaired degradation processes
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