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In a study by Momma et al., the view that γVA is produced only by gut microbes was broken by co-incubating human serum, HUVEC cell lysate, or PON-transfected HEK293FT cell lysate with 3,4-DHPV (1–500 μM) at 37°C, confirming that PON1/3 in serum can enzymatically hydrolyze 3,4-DHPV to γVA by enzymatic hydrolysis, forming a new pathway of host metabolism (Momma et al., 2023)
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1,6 Widespread upregulation of NRF2 expression may provide protection for susceptible tissues against the progressive oxidative damage in FRDA
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