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For most people, 500mg represents a clinically relevant yet approachable dose — but not so high that dose-related GI side effects become a major concern.10 41 Additionally, the 250mg capsule format makes it easy for users to adjust their intake up or down to align with the amounts tested in studies, such as: 500mg/day: lowered multiple liver enzymes linked to inflammation and damage in people with primary biliary cholangitis (PBC) compared to placebo.9 750mg/day: reduced alkaline phosphatase and improved other liver blood markers in another study, without adding side effects.5 1,750mg/day: improved insulin sensitivity by roughly 30% in people with insulin resistance compared to placebo.6 There are a couple of trade‑offs to note up front for Double Wood

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The working hypothesis, discussed in the Giblin et al