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Relativně častá je otevřená neurální trubice, v deformovaných strukturách je veliká apoptóza, zvláště v přítomnosti vysoké intracelulární hladiny vápníku
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Acute injuries may respond adequately with shorter protocols (6-8 weeks), while chronic degenerative conditions like osteoarthritis may benefit from extended maintenance periods of 12 weeks or longer
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