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Platinum compounds have also the ability to bind to mitochondrial DNA (mtDNA), which cannot be repaired because there are no DNA repair systems in mitochondria, thus increasing the amount of reactive oxygen species (ROS) and oxidative stress (Podratz et al., 2011)
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Ketones, in particular βHB, are able to cross the blood–brain barrier and provide an alternative source of energy, compensating for glucose deficits [29,132]
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