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For example, cytoplasmic Hsp60 has been shown to interact with the IκB kinase (IKK) complex, promoting the activation of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), a key transcription factor involved in inflammation and immune responses [52]
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It is also possible that there are two or more redundant glutathione transporters in the mammalian peroxisomal membrane and thus only the simultaneous knockout of the relevant genes will reveal a defect in glutathione transport across the peroxisomal membrane
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