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Indeed, this system accounts for approximately 20% of abluminal Na-dependent Gln transport activity, whereas system N mediates the majority of Gln transport across the abluminal membrane ( Transport of Large and Small Neutral AAs: System ASC This is a Na + -dependent system located exclusively on the luminal membranes of the BBB, whose name “ASC” was derived from the three main substrates Ala, Ser, and Cys, although Gly and several essential AAs are also putative substrates, including Met, Val, Leu, Iso, and Thr (Tayarani et al., 1987)
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