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Adderall crash When your dose of Adderall wears off, a sudden drop in dopamine and norepinephrine leads to an Adderall cras h or rebound effect This sudden shift often leaves people feeling : Exhausted Cranky Easily frustrated by small things This often occurs in the late afternoon or early evening and is more common with immediate-release formulations

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Pi-Sunyer X, Astrup A, Fujioka K et al