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There is a large body of evidence that high grade oxidative stress (OxS) has one of the crucial roles in the pathogenesis of several disorders/diseases of the GI tract (inflammatory bowel disease, coeliac disease, etc.), the vascular system (atherosclerosis, myocardial infarction, stroke, vascular dysfunctionality), the nervous system (Alzheimer's disease, Parkinson's disease), the liver (ethanol damage, cirrhosis), the skin (several dermatoses), the pancreas (diabetes mellitus) and the eyes (age-related macular degeneration, retinopathy) (144–152)
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