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Induction of Diabetes To induce diabetes, after fasting overnight (access to water only), a single-dose intraperitoneal injection of freshly prepared streptozotocin (STZ) was given (60 mg/kg of body weight dissolved in 0.1 M sodium citrate buffer, pH 4.6) (STZ, S0130-500 MG, Sigma-Aldrich Co, USA)

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