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Among approaches to counteract ADO-mediated immunosuppression ( Supplementary Table 1 ), ADA-based degradation (97, 102) is currently the most feasible, given the complexity of receptor-specific blockade (50, 103), the limited potency of small-molecule CD38 inhibitors (104), and the presence of alternative ADO-generating pathways (105)
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One analysis used pooled data from five randomized placebo-controlled trials in which ginkgo, at 240 mg daily for 22–26 weeks, was tested as a therapy for dementia
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