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Later data from another group confirmed its protective effects in acute lung injury and further revealed that ERK phosphorylation (one of the three branches of MAPK pathways) was also suppressed during this process and that of the three proteins regulating NF-κB, the suppression of TNF receptor-associated factor 6 (TRAF6) expression and its polyubiquitination of TRAF6 at lysine 63 (K63-linked polyubiquitination, which may cause IκB kinase (IKK) phosphorylation and activation (Min et al., 2018)), rather than lysine 48, was responsible for ISA-mediated NF-κB inhibition ( In mouse asthmatic inflammation induced by ovalbumin, ISA treatment can reduce the infiltrated eosinophils (stimulated by CCL17 and CCL22) rather than macrophages, serum ovalbumin-specific IgE, the protein concentration as well as type 2 cytokines (IL-4, IL-5, IL-13, CCL17 and CCL22) in BALF (Song et al., 2021)

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doi: 10.1097/MED.0000000000000191 430 ChengYLiangSZhangSHuiX