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Osteoporosis & Bone Health: Prevention & Treatment - Life Extension

doi: 10.1210/endo-121-4-1329 [DOI] [PubMed] [Google Scholar] 67.Maywood ES, Chesham JE, O’Brien JA, Hastings MH

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Benefits (Research Focus) • NNMT inhibition — studied as a selective small-molecule inhibitor of nicotinamide N-methyltransferase • NAD+ preservation — investigated for preservation of cellular NAD+ pools and downstream sirtuin pathway activity • Adipose tissue research — explored for lipolysis markers and fat-mass partitioning in DIO rodent models • Skeletal muscle metabolism — examined for endpoints related to muscle aging and sarcopenia models • Metabolic signaling — researched for glucose homeostasis and insulin sensitivity endpoints in metabolic disease models What Researchers Look At • NNMT enzymatic activity and 1-methylnicotinamide (1-MNA) tissue concentrations • Intracellular NAD+ / NADH ratio and downstream sirtuin (SIRT1/SIRT3) activation • Body composition, fat mass, and lean mass partitioning in DIO rodent models • Adipocyte lipolysis markers and adipose tissue inflammation profiles • Glucose tolerance, insulin sensitivity, and hepatic steatosis endpoints Quick Specs • Form: Lyophilized white powder • Net Content: 10 mg per vial (as iodide salt) • Quantity: 1 vial • Appearance: White to off-white lyophilizate • Reconstitution: Bacteriostatic or sterile water (added by the end researcher) • Purity: ≥99% by HPLC • Identity: MS-verified (per COA) • Storage: Protect from light Identity Basics • Compound: 5-Amino-1MQ (5-Amino-1-methylquinolinium iodide) • Synonyms: 5-Amino-1-methylquinolinium