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Electrons derived from oxidation of pyruvate mediated by pyruvate dehydrogenase (PDH) and fatty acid oxidation are transferred via NADH to Complex I (FMN-dependent NADH-ubiquinone oxidoreductase), while electrons from succinate in the Krebs cycle, amino acid metabolism, and fatty acid oxidation are transferred to Complex II (FAD-dependent succinate-ubiquinone oxidoreductase) via FADH2
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For gel source data ( c , d , k ) showing the overlap of colorimetric and chemiluminescence signals, see Supplementary Fig
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