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A key player in the ferroptosis pathway is nuclear erythroid 2-related factor 2 (NRF2), a transcription factor that controls the expression of many antioxidant genes and components of ferroptosis [75]
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Employing quantitative mass spectrometry and lipidomics, researchers identified that the mitochondrial kinase PCK2 mediates the phosphorylation and functional activation of ACSL4, thereby orchestrating membrane phospholipid reorganization linked to ferroptosis (84)
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