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Frontiers | Growth Hormone and Insulin-Like Growth Factor Action in Reproductive Tissues
Approximately 50% of cellular actin exists as monomeric G-actin, and Thymosin Beta-4 binds most of this pool in a 1:1 stoichiometric complex through its conserved LKKTET motif (residues 17-22)
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however, in DKD, hyperglycemia induces a hypoxic state that inhibits OXPHOS, pushing cells to increase glycolysis to generate ATP rapidly
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