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These hormonal elevations in response to RE take place in a unique physiological environment, whereby acute elevations in circulating blood hormone concentrations, resulting from a combination of either e.g., increased secretion, reduced hepatic clearance, reduced plasma volume or reduced degradation rates—interact with receptors on the target tissue cell membranes or with nuclear/cytoplasmic receptors located within the target tissue (e.g., steroid receptors)

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Barrier-first beats actives-first: repair the barrier and calm the inflammation before you add actives