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Moreover, it was found that a combination of EGCG and COX-2 inhibitor (NS-398) exhibited a synergic anticancer activity, which was indicated by an elevated apoptotic response (increase in the expression of pro-apoptotic BAX protein, pro-caspase-6, and pro-caspase-9 and the cleavage of poly(ADP)ribose polymerase (PARP)) and the inhibition of NF-κB activity [118]
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