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Sublingual B12 dissolves under the tongue to absorb through the oral mucosa, bypassing gut absorption pathways that require intrinsic factor Research shows sublingual B12 performs as well as oral B12 for most people, and comparably to injection in at least one direct trial, but is not clearly superior for healthy adults with normal gut function People with pernicious anemia, atrophic gastritis, Crohn's disease, celiac disease, or gastric bypass history have the strongest case for choosing sublingual over standard oral supplements 1000mcg daily is the standard maintenance dose